國家衛生研究院 NHRI:Item 3990099045/11965
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    NHRI > Immunology Research Center > Tse-Hua Tan > Periodical Articles >  Item 3990099045/11965


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11965


    Title: Regulation of Dual-Specificity Phosphatase (DUSP) ubiquitination and protein stability
    Authors: Chen, HF;Chuang, HC;Tan, TH
    Contributors: Immunology Research Center
    Abstract: Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or spatiotemporal profiles of MAPK activities. Hence, DUSPs need to be properly controlled. Protein post-translational modifications, such as ubiquitination, phosphorylation, methylation, and acetylation, play important roles in the regulation of protein stability and activity. Ubiquitination is critical for controlling protein degradation, activation, and interaction. For DUSPs, ubiquitination induces degradation of eight DUSPs, namely, DUSP1, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, and DUSP16. In addition, protein stability of DUSP2 and DUSP10 is enhanced by phosphorylation. Methylation-induced ubiquitination of DUSP14 stimulates its phosphatase activity. In this review, we summarize the knowledge of the regulation of DUSP stability and ubiquitination through post-translational modifications.
    Date: 2019-05-30
    Relation: International Journal of Molecular Sciences. 2019 May 30;20(11):Article number 2668.
    Link to: http://dx.doi.org/10.3390/ijms20112668
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000472634100062
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85066946256
    Appears in Collections:[Tse-Hua Tan] Periodical Articles
    [Huai-Chia Chuang] Periodical Articles

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