國家衛生研究院 NHRI:Item 3990099045/11959

NHRI > Institute of Biotechnology and Pharmaceutical Research > Shau-Hua Ueng > Conference Papers/Meeting Abstract > Item 3990099045/11959

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11959

Title:	4-Bromophenylhydrazinyl benzenesulfonylphenylureas inhibit indoleamine 2,3-dioxygenase in vitro and in vivo
Authors:	Ueng, SH;Kuo, CC;Lin, SY;Yeh, TK;Song, JS;Hung, MS;Chen, CT
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	pharmaceutical companies, including Pfizer, Merck, and Bristol-Myers Squibb, are known to be in pursuit of IDO inhibitors, and Incyte recently reported good results in the phase II clinical trial of the IDO inhibitor Epacadostat. In previous work, we developed a series of IDO inhibitors based on a high-throughput screening core structure, sulfonylhydrazide. Further, we developed the 4-bromophenylhydrazinyl benzenesulfonylphenylurea, as a potent IDO inhibitor with an IC50 value within 100 nM in inhibiting IDO in vitro. This compound demonstrated a 30% reduction in tumor weight in a murine CT26 syngeneic model on day 18 with 100 mg/kg oral administration twice daily, indicating that the 4-bromophenylhydrazinyl benzenesulfonylphenylurea may have potential for further investigation in the development of anti-tumor drugs.
Date:	2018-07
Relation:	Cancer Research. 2018 Jul;78(13, Suppl.):Meeting Abstract 1664.
Link to:	http://dx.doi.org/10.1158/1538-7445.Am2018-1664
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000468818904059
Appears in Collections:	[Shau-Hua Ueng] Conference Papers/Meeting Abstract [Ching-Chuan Kuo] Conference Papers/Meeting Abstract [Ming-Shiu Hung] Conference Papers/Meeting Abstract [Chiung-Tong Chen] Conference Papers/Meeting Abstract [Teng-Kuang Yeh] Conference Papers/Meeting Abstract [Shu-Yu Lin] Conference Papers/Meeting Abstract

Files in This Item:

There are no files associated with this item.

Loading...