國家衛生研究院 NHRI:Item 3990099045/11847
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    题名: Enhancer role of a native metabolite, O-acetyl-ADP-ribose, on the Saccharomyces cerevisiae chromatin epigenetic gene silencing
    作者: Wang, SH;Tung, SY;Su, KC;Shen, HH;Hong, JY;Tsai, MS;Liou, GG
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: To study the epigenetic gene silencing, yeast is an excellent model organism. Sir proteins are required for the formation of silent heterochromatin. Sir2 couples histone deacetylation and NAD hydrolysis to generate an endogenous epigenetic metabolic small molecule, O-acetyl-ADP-ribose (AAR). AAR is involved in the conformational change of SIR complexes, modulates the formation of SIR-nucleosome pre-heterochromatin and contribute to the spreading of SIR complexes along the chromatin fiber to form extended silent heterochromatin regions. Here, we demonstrate that AAR is capable of enhancing the chromatin silencing effect under either an extra exogenous AAR, or a defect AAR metabolic enzyme situation, but decreasing the chromatin silencing effect under a defect AAR synthetic enzyme state. Our results provide an evidence of biological function importance of AAR. It is indicated that AAR does not only function in vitro but also plays a role in vivo to increase the effect of heterochromatin epigenetic gene silencing. However, further investigations of AAR are warranted to expand our knowledge of epigenetics and associated small molecules.
    日期: 2019-06
    關聯: Genes to Cells. 2019 Jun;24(6):449-457.
    Link to: http://dx.doi.org/10.1111/gtc.12685
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1356-9597&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000471799600004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85065391187
    显示于类别:[劉淦光(2006-2014)] 期刊論文

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