國家衛生研究院 NHRI:Item 3990099045/11746
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    NHRI > NHRI Graduate Student Program > Others > Periodical Articles >  Item 3990099045/11746


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11746


    Title: Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin
    Authors: Lin, JH;Lee, WJ;Wu, HC;Wu, CH;Chen, LC;Huang, CC;Chang, HL;Cheng, TC;Chang, HW;Ho, CT;Tu, SH;Ho, YS
    Contributors: NHRI Graduate Student Program
    Abstract: The function of small G protein signalling modulators (SGSM1/2/3) in cancer remains unknown. Our findings demonstrated that SGSM2 is a plasma membrane protein that strongly interacted with E-cadherin/β-catenin. SGSM2 downregulation enhanced the phosphorylation of focal adhesion kinase (FAK; Y576/577), decreased the expression of epithelial markers such as E-cadherin, β-catenin, and Paxillin, and increased the expression of Snail and Twist-1, which reduced cell adhesion and promoted cancer cell migration. Oestrogen and fibronectin treatment was found to promote the colocalization of SGSM2 at the leading edge with phospho-FAK (Y397). The BioGRID database showed that SGSM2 potentially interacts with cytoskeleton remodelling and cell-cell junction proteins. These evidences suggest that SGSM2 plays a role in modulating cell adhesion and cytoskeleton dynamics during cancer migration.
    Date: 2019-07
    Relation: Cell Adhesion and Migration. 2019 Jul;13(1):120-137.
    Link to: http://dx.doi.org/10.1080/19336918.2019.1568139
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1933-6918&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000470670000007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85061456226
    Appears in Collections:[Others] Periodical Articles

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