國家衛生研究院 NHRI:Item 3990099045/11727
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    题名: The anti-proliferative effect of CAPE on docetaxel-resistant prostate cancer cells
    作者: Fu, YK;Tseng, JC;Huang, SH;Lin, CY;Chuu, CP
    贡献者: Institute of Cellular and Systems Medicine
    摘要: The majority of patients with prostate cancer (PCa) receiving androgen ablation therapy will relapse castration-resistant prostate cancer (CRPC) within 1-3 years. Docetaxel is a FDA-approved chemotherapeutic drug for CRPC, however, PCa patient receiving docetaxel develop drug-resistant phenotype after a few months. Caffeic acid phenethyl ester (CAPE) is the main component for honey bee propolis. We previously showed that CAPE can suppresses growth of PCa tumors. In this study, we explored if CAPE can suppress docetaxel-resistant PCa cells. We observed that CAPE dose-dependently suppressed proliferation of docetaxel-resistant PC-3 cells, as well as growth of this docetaxel-resistant PC-3 xenograt in nude mice. We found that CAPE treatment promoted apoptosis-related proteins and thus induced apoptosis in docetaxel-resistant PC-3 cells. In conclusion, CAPE is an potential treatment for docetaxel-resistant PCa.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):574.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773602350
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