國家衛生研究院 NHRI:Item 3990099045/11712
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11712


    Title: Evolution of nanoparticle-mediated photodynamic therapy: From superficial to deep-seated cancers
    Authors: Sivasubramanian, M;Chuang, YC;Lo, LW
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: Enthusiasm for photodynamic therapy (PDT) as a potential therapeutic intervention for cancer has increased exponentially in recent decades. Photodynamic therapy constitutes a clinically approved, minimally invasive treatment modality that uses a photosensitizer (light absorbing molecule) and light to kill cancer cells. The principle of PDT is, when irradiated with a light of a suitable wavelength, a photosensitizer absorbs the light energy and generates cytotoxic free radicals through various mechanisms. The overall efficiency of PDT depends on characteristics of activation light and in-situ dosimetry, including the choice of photosensitizer molecule, wavelength of the light, and tumor location and microenvironment, for instance, the use of two-photon laser or an X-ray irradiator as the light source increases tissue-penetration depth, enabling it to achieve deep PDT. In this mini-review, we discuss the various designs and strategies for single, two-photon, and X-ray-mediated PDT for improved clinical outcomes.
    Date: 2019-01-31
    Relation: Molecules. 2019 Jan 31;24(3):Article number 520.
    Link to: http://dx.doi.org/10.3390/molecules24030520
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000458934000144
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85060957742
    Appears in Collections:[Leu-Wei Lo] Periodical Articles

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