國家衛生研究院 NHRI:Item 3990099045/11705
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 907354      在线人数 : 916
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11705


    题名: Radio-sensitivity of IGFBP3 in oral squamous cell carcinoma cells
    作者: Wang, SH;Chen, YL;Yen, YC;Chen, YW
    贡献者: National Institute of Cancer Research
    摘要: We have previously demonstrated that ectopic insulin-like growth factor binding protein 3 (IGBBP3) expression enhanced lymph node metastasis of OSCC cells. However, the survival analysis of OSCC patients with high levels of IGFBP3 had an increased survival rate compared to those with low levels of IGFBP3. Furthermore, we found that ectopic IGFBP3 expression enhanced the radiation-induced cell-killing effect, indicating that the sensitive effects of IGFBP3 on radiation treatment might contribute to the better survival of OSCC after conventional treatment. In vivo, we discovered that ectopic IGFBP3 expression after 8-Gy radiation treatments can reduce tumor weight, volume and metastasis ability, but did not decrease tumor lymphangiogenesis. In vitro, ectopic IGFBP3 expression did not affect radiation-induced cell cycle arrest, but enhance radiation-induced cell death as evidenced by doubling staining with PI and annexin V. Additionally, we found that ectopic IGFBP3 expression increased the reactive oxygen species production and decreased mitochondrial membrane potential by flow cytometry. We will further investigate the roles of IGFBP3 in mitochondria upon radiation treatment.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):511.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773602227
    显示于类别:[陳雅雯] 會議論文/會議摘要

    文件中的档案:

    档案 大小格式浏览次数
    ISI000453773602227.pdf37KbAdobe PDF274检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈