國家衛生研究院 NHRI:Item 3990099045/11696
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11696


    题名: AXL regulates IRS-associated metabolism in pancreatic cancer cells via a novel target TNS2
    作者: Cheng, LC;Chen, YL;Chuang, SE
    贡献者: National Institute of Cancer Research
    摘要: AXL is known to be involved in the later stages of tumor progression such as migration/invasion, metastasis and/or drug resistance. Studies show that TNS2 is a binding partner of many proteins, including the tyrosine kinase Axl, but the details of their interactions have not been elucidated. Tensin 2 is a member of the Tensin family. Here, we demonstrate that TNS2 is a phosphorylation substrate of Axl. We further confirmed the correlationship of TNS2 expression and the expression of Axl, insulin receptor substrat-1 (IRS-1), pyruvate dehydrogenase kinase 1 (PDK1), pyruvate kinase M2 (PKM2) and glucose transporter type 4 (GLUT4) in pancreatic cancer patients. Based on these results, we suggest that Axl may modulate glucose metabolism potentially through TNS2 and IRS-1. We hypothesize that there exists a novel mechanism whereby Axl binds and phosphorylate TNS2 at Y483, releasing TNS2 from interacting with IRS-1 and resulting in increased stability of IRS-1. The three key enzymes of aerobic glycolysis, GLUT4, PDK1 and PKM2, were found to be up-regulated by the Axl/TNS2/IRS-1 cross-talk and may potentially play a critical role in glucose metabolism of cancer cells.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):403.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773602007
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