國家衛生研究院 NHRI:Item 3990099045/11668
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    題名: Interaction of smoking and hOGG1 Ser326Cys polymorphisms in the risk of lung cancer on a population-based case-control study
    作者: Chang, CH;Hsiao, CF;Chang, GC;Tsai, YH;Huang, MH;Su, WC;Chen, YM;Chen, HL;Yang, PC;Chen, CJ;Hsiung, CA
    貢獻者: Institute of Population Health Sciences
    摘要: Cigarette smoking is a major risk factor of lung cancer, but only a few proportion of smokers (1%∼15%) become lung cancer patients. Obviously, other risk factors maybe jointly cause lung cancer in smokers. Smoking is known to associate with DNA lesions and the DNA repair gene, hOGG1 Ser326Cys polymorphisms, had been reported as a genetic risk factor of lung cancer. However, the results were not consistent in the past research. This work examined the modified and joint effects between smoking and hOGG1 Ser326Cys polymorphisms in the risk of lung cancer on a population-based case-control study in Taiwan. The analyses were based on 1,119 lung cancer cases and 1,007 healthy controls. The participants were recruited from six medical centers from 2002 to 2004 in Taiwan. The hOGG1 Ser326Cys polymorphisms were in Hardy-Weinberg equilibrium in healthy controls. Under the different smoking categories (none, mild, and heavy), this study used the logistic regression models after adjusting for age, sex, and education. No significant associations between hOGG1 Ser326Cys polymorphisms and lung cancer in none and mild smoking categories were found. The ORs (95%) of Cys/Cys against Ser/Ser were 1.12 (0.75-1.67) for none smokers and 1.45 (0.74-2.82) for mild smokers (under 40 pack-year). In contrast, there was a significant association in heavy smokers (above 40 pack-year) with the OR (95%) of 3.58 (1.56-8.20). The synergy index for the interaction between Cys/Cys and heavy smoking was statistically significant (p-value=0.04). The similar results were also found in subtypes (adenocarcinoma, squamous, and small cell) of lung cancer. Although the synergy indexes were not statistically significant in adenocarcinoma (p-value=0.21) and squamous cell (p-value=0.06), it was statistically significant in small cell (p-value=0.02). Our findings indicated a noticeable interaction between hOGG1 Ser326Cys polymorphisms and heavy smoking. It is worth investigating whether other DNA repair genes modify the smoking effect in the risk of lung cancer.
    日期: 2006-04
    關聯: Cancer Research. 2006 Apr;66(8, Suppl.):482-483.
    Link to: http://cancerres.aacrjournals.org/content/66/8_Supplement/482.4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0008-5472&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000454606203494
    顯示於類別:[蕭金福] 會議論文/會議摘要
    [熊昭] 會議論文/會議摘要

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