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http://ir.nhri.org.tw/handle/3990099045/11665
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| Title: | Non-smoking COPD: An overlooked systemic disease, modifiable by physical activity based on studying a cohort of 386,304 subjects |
| Authors: | Shu, CC;Su, TC;Lee, JH;Tsai, MK;Wen, CP |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Background: Smoking cessation is the mainstay treatment for COPD among smokers, but, for nonsmoking COPD, effective management beyond symptomatic treatment is still unsettled. Methods: A cohort of 386,304 adults in Taiwan went through health surveillance program between 1994 and 2008, with health data collected including spirometry and medical and lifestyle history. Fully active individuals exercised 30 min/day at 4 MET intensity. A total of 16,089 COPD, 4.2% of the cohort, was defined by GOLD with FVC/FEV1 <0.70. More than half (62%) of COPD were nonsmokers. COPD deaths, 1527 out of 10,743, were identified as of 2008 from National Death File by matching with cohort IDs. Hazard ratios (HR) used Cox model. Results: Hazard ratios of non-smoking COPD were significantly increased for specific cause of death such as COPD (HR:11.86) but also from all-cause (1.44), CVD (1.68) including heart (1.55) and stroke (1.69), and Kidney diseases (2.06), a sign of systemic extra-pulmonary involvement. The significant increase of all-cause risk of COPD (1.44) became non-significant when these COPD became fully active, compared to inactive non-COPD (1.08, 95%CI: 0.9 – 1.3), implying that COPD risks could be eliminated through physical activity. Conclusions: Non-smoking COPD, a sizable majority among all COPDs in this Asian cohort, is a systemic disease with multi-system extra-pulmonary involvement. Their mortality risks disappeared in the long run by those COPDs engaged in regular exercise of at least 30 min/day of moderate intensity. |
| Date: | 2018-09 |
| Relation: | European Respiratory Journal. 2018 Sep;52(Suppl. 62):Meeting Abstract PA762. |
| Link to: | http://dx.doi.org/10.1183/13993003.congress-2018.PA762 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0903-1936&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000455567107442 |
| Appears in Collections: | [溫啟邦(2001-2010)] 會議論文/會議摘要
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