國家衛生研究院 NHRI:Item 3990099045/11656
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    題名: Education levels may modify the association between cardiac index and cognitive function among the elders with normal ejection function
    作者: Chuang, SY;Cheng, HM;Liao, CF;Pan, WH;Liu, WL;Chen, CH
    貢獻者: Institute of Population Health Sciences
    摘要: Objectives: We investigated modulating effect of education levels on the association between Cardiac index (CI) and cognitive function among older adults. Methods:A total of 725 elders (≥60 years) with normal ejection-fraction (50%) were identified from the Cardiovascular Diseases Risk Factor Two-Township Study.CI was calculated as the product of Doppler-derived stroke volume and heart rate divided by body surface area. The global cognitive function was assessed by the Mini-Mental Short Examination (MMSE). General linear and logistic regressions were used to evaluate the association of CI with MMSE and cognitive function impairment (MMSE< = 26. Results: CI was positively associated with MMSE (age, sex and education years adjusted-beta[a-Beta] = 0.16, p-value[p] = 0.0167) in those elders with low levels of education (≤ 9 years of education), but not in those elders with high levels of education (>9 years of education) (a-Beta = 0.031, p = 0.5039). In the multivariable linear regression with further adjustments for history of stroke and heart disease, low-density lipoprotein, glucose levels, left ventricular mass index, and ventricular-arterial coupling, CI persisted to associate significantly with MMSE in elders with low levels of education (beta = 0.73, p = 0.044). Furthermore, a low CI (less than 3.1 L/min/m2) was significantly associated with cognitive function impairment in those elders with low levels of education (odds ratio[OR] = 2.36, 95% confidence intervals = 1.08–5.15), but not in those with high levels of education (OR = 1.15, p = 0.7664) in the multivariable models. Conclusion: Low CI was associated with low MMSE and cognitive function impairment in elders with low education levels but not in those with high education levels. Higher education levels may obscure the impact of low CI on cognitive function.
    日期: 2018-10
    關聯: Journal of Hypertension. 2018 Oct;36:E263.
    Link to: http://dx.doi.org/10.1097/01.hjh.0000549070.47852.82
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0263-6352&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000455594805050
    顯示於類別:[莊紹源] 會議論文/會議摘要

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