國家衛生研究院 NHRI:Item 3990099045/11641
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11641


    Title: Early growth response protein 1 (EGR1) is involved in the 14-3-3 epsilon-regulated tumor progression of HCC
    Other Titles: Early growth response protein 1 (EGR1) is involved in the 14-3-3ε-regulated tumor progression of HCC
    Authors: Wu, YJ;Liou, JY
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: We have previously reported that overexpression of 14-3-3ε is correlated with high risk of extrahepatic metastasis and worse survival in hepatocellular carcinoma (HCC). Early growth response protein 1 (EGR1) is a transcriptional regulator which contributes to modulating cell proliferation and differentiation. However, whether EGR1 modulates HCC progression has not yet been elucidated. In this study, we found that EGR1 is a potential downstream regulator of 14-3-3ε. Both of transient and stable overexpression of 14-3-3ε significantly induced EGR1 expression which was determined by Western blotting and real-time PCR analysis. Furthermore, we found that EGR1 was involved in 14-3-3ε-promoted HCC progression through activation of MEK/ERK pathway. Moreover, we found that sorafenib attenuated 14-3-3ε-induced EGR1 expression. These results suggest that EGR1 plays as a crucial factor that contributes in 14-3-3ε-promoted HCC tumor progression.
    Date: 2018-12
    Relation: Cancer Science. 2018 Dec;109(Suppl. 2):403.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773602006
    Appears in Collections:[Jun-Yang Liou] Conference Papers/Meeting Abstract

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