國家衛生研究院 NHRI:Item 3990099045/11640
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    题名: Rooibos suppresses the proliferation of human castration-resistant prostate cancer cells
    作者: Huang, SH;Chuu, CP
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Androgen-deprivation therapy (ADT) is the standard treatment for metastatic PCa. Although it is very effective to induce tumor regression, the majority of PCa patients receiving ADT will develop CRPC within 1-3 years. Currently, there is no effective treatment for CRPC. We investigated if rooibos exhibits anti-cancer effect on CRPC. We used LNCaP 104-R1 (R1), a human AR-rich androgen-independent PCa cells, to mimic the clinical situation of CRPC. We demonstrated that rooibos treatment suppressed the proliferation of R1 cells, as determined by MTT and Hoechst dye-based proliferation assay. Flow cytometry analysis indicated that rooibos treatment increases cell population in sub-G1 and G2/M phase but decreases in S phase. Gavage of rooibos reduced tumor growth of R1 xenografts in nude mice experiments. Micro-Western Array revealed that treatment with rooibos decreased expression of proteins including Akt, Bcl-2, but increased protein expression of cytochrome C. Conventional Western blotting suggested that rooibos treatment increased cytochrome C, LC3, and activated caspase 3 expression. In conclusion, rooibos maybe an alternative therapy for CRPC.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):575.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773602353
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