國家衛生研究院 NHRI:Item 3990099045/11639

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Title:	Different role of androgen receptor in regulation of prostate cancer metastasis with or without androgen
Authors:	Huo, C;Kuo, YY;Chuu, CP
Contributors:	Institute of Cellular and Systems Medicine
Abstract:	Androgen receptor (AR), an androgen-activated transcription factor, plays essential roles in the development, progression, and metastasis of prostate cancer (PCa). Previously, we reported that in the absence of androgen, re-expression of AR in PC-3 cells suppresses cell migration and invasion. In this study, we determine the effect of AR on PCa cell invasion under androgen treatment. Surprisingly, androgen stimulates migration and invasion of PC-3 cells re-expressing AR. Micro-Western Array analysis indicates that androgen increases Slug, Snail, Twist, N-cadherin and YAP, and decrease E-cadherin in PC-3 cell re-expressing AR. Co-IP assay also showed AR interacts with YAP in this PCa cell. Our finding suggests that AR has opposite regulatory role on PCa invasion in the absence vs. presence of androgen.
Date:	2018-12
Relation:	Cancer Science. 2018 Dec;109(Suppl. 2):996.
Link to:	https://doi.org/10.1111/cas.13904
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000453773604379
Appears in Collections:	[Chih-Pin Chuu] Conference Papers/Meeting Abstract

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