國家衛生研究院 NHRI:Item 3990099045/11626
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 856350      線上人數 : 508
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11626


    題名: Establishment and characterization of novel syngeneic oral squamous cell carcinoma mouse cell lines
    作者: Chen, YW;Chuang, TH;Liu, KJ;Yen, YC;Wang, SH;Kuo, CC
    貢獻者: Institute of Biotechnology and Pharmaceutical Research;National Institute of Cancer Research;Immunology Research Center
    摘要: M1-2 and M2-3 cells were established from mouse tongue tumor specimens induced by 4-NQO and arecoline. M1-2 and M2-3 cells partially developed tumors after subcutaneous injection in immune-compromised mice. In contrast, M1-2 and M2-3 cells failed to develop any tumor by orthotopic inoculation of syngeneic mice. By in vitro selection, M1-2sph and M2-3sph cells were established and only M1-2sph cells successfully developed tumors in syngeneic mice. M1-2sph and M2-3sph cells showed the higher activities of cell growth and sphere formation than their parental cells. The higher Klf4 and Nanog expression was detected only in M1-2sph cells. M1-2sph and M2-3sph cells showed the higher capabilities of migration and invasion than their parental cells. The epithelial mesenchymal transition (EMT) was occurred only in M1-2sph cells. The higher Twist and Slug expression was detected only in M1-2sph cells. The profiling of p ERK1/2 activation was changed between M1-2 and M1-2sph cells but not between M2-3 and M2-3sph cells. The relationship between ERK1/2 activation and occurrence of EMT and sphere formation was under investigation.
    日期: 2018-12
    關聯: Cancer Science. 2018 Dec;109(Suppl. 2):386.
    Link to: https://doi.org/10.1111/cas.13904
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453773601339
    顯示於類別:[郭靜娟] 會議論文/會議摘要
    [陳雅雯] 會議論文/會議摘要
    [劉柯俊] 會議論文/會議摘要
    [莊宗顯] 會議論文/會議摘要

    文件中的檔案:

    檔案 大小格式瀏覽次數
    ISI000453773601339.pdf36KbAdobe PDF301檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋