國家衛生研究院 NHRI:Item 3990099045/11581
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    题名: Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems
    作者: Lin, YJ;Mi, FL;Lin, PY;Miao, YB;Huang, T;Chen, KH;Chen, CT;Chang, Y;Sung, HW
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.
    日期: 2019-06-15
    關聯: Advanced Drug Delivery Reviews. 2019 Jan 15;139(SI):71-82.
    Link to: http://dx.doi.org/10.1016/j.addr.2018.12.001
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0169-409X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000482249300006
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85058015186
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