國家衛生研究院 NHRI:Item 3990099045/11563
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    題名: Ribose-5-Phosphate Isomerase a overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and beta-catenin pathways
    其他題名: Ribose-5-Phosphate Isomerase a overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways
    作者: Chou, YT;Chen, LY;Tsai, SL;Tu, HC;Lu, JW;Ciou, SC;Wang, HD;Yuh, CH
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Dysregulation of the enzymes involved in the pentose phosphate pathway (PPP) is known to promote tumorigenesis. Our recent study demonstrated that ribose-5-phosphate isomerase (RPIA), a key regulator of the PPP, regulates hepatoma cell proliferation and colony formation. Our studies in zebrafish reveal that RPIA-mediated hepatocarcinogenesis requires extracellular signal-regulated kinase (ERK) and beta-catenin signaling. To further investigate RPIA-mediated hepatocarcinogenesis, two independent lines of transgenic zebrafish expressing human RPIA in the liver were generated. These studies reveal that RPIA overexpression triggers lipogenic factor/enzyme expression, steatosis, fibrosis and proliferation of the liver. In addition, the severity of fibrosis and the extent of proliferation are positively correlated with RPIA expression levels. Furthermore, RPIA-mediated induction of hepatocellular carcinoma (HCC) requires the ERK and beta-catenin signaling pathway but is not dependent upon transaldolase levels. Our study presents a mechanism for RPIA-mediated hepatocarcinogenesis and suggests that RPIA represents a valuable therapeutic target for the treatment of HCC.
    日期: 2019-03
    關聯: Carcinogenesis. 2019 Mar; 40(3):461-473.
    Link to: http://dx.doi.org/10.1093/carcin/bgy155
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0143-3334&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000472794100008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85066817959
    顯示於類別:[喻秋華] 期刊論文

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