國家衛生研究院 NHRI:Item 3990099045/11508
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    题名: Identification of the novel role of CD24 as an oncogenesis regulator and therapeutic target for triple negative breast cancer
    作者: Chan, SH;Tsai, KW;Chiu, SY;Kuo, WH;Chen, HY;Jiang, SS;Chang, KJ;Hung, WC;Wang, LH
    贡献者: Institute of Molecular and Genomic Medicine;National Institute of Cancer Research
    摘要: Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, with unfavorable prognosis and 5-year survival. The purpose of this study was to investigate the underlying mechanisms involved in TNBC progression. We determined that CD24 expression was elevated in highly lung and lymph node metastatic TNBC cells. CD24 depletion inhibited primary tumor growth and lymph node and lung metastasis and reduced the number of blood and lymphatic vessels in the tumor microenvironment. CD24 knockdown impaired EGFR/Met-mediated signaling and reduced lymphangiogenesis- and angiogenesis-related molecules, including vascular endothelial growth factors A and C, by promoting EGFR and Met protein instability via the lysosomal degradation pathway. CD24 monoclonal antibody treatment reduced lung metastasis and prolonged the survival in a lung metastasis mouse model. Clinical analyses revealed that the CD24high/METhigh "double-positive" signature identified a subset of TNBC patients with worst outcomes. We conclude that CD24 could be a therapeutic target by itself and in combination with the Met expression could be a good prognostic biomarker for TNBC patients.
    日期: 2019-01
    關聯: Molecular Cancer Therapeutics. 2019 Jan;18(1):147-161.
    Link to: http://dx.doi.org/10.1158/1535-7163.Mct-18-0292
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1535-7163&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000454836100013
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85059496965
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