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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/11456
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| Title: | Deep-coverage whole genome sequences and blood lipids among 16,324 individuals |
| Authors: | Natarajan, P;Peloso, GM;Zekavat, SM;Montasser, M;Ganna, A;Chaffin, M;Khera, AV;Zhou, W;Bloom, JM;Engreitz, JM;Ernst, J;O’Connell, JR;Ruotsalainen, SE;Alver, M;Manichaikul, A;Johnson, WC;Perry, JA;Poterba, T;Seed, C;Surakka, IL;Esko, T;Ripatti, S;Salomaa, V;Correa, A;Vasan, RS;Kellis, M;Neale, BM;Lander, ES;Abecasis, G;Mitchell, B;Rich, SS;Wilson, JG;Cupples, LA;Rotter, JI;Willer, CJ;Kathiresan, S;Abe, N;Albert, C;Allred, NNP;Almasy, L;Alonso, A;Ament, S;Anderson, P;Anugu, P;Applebaum-Bowden, D;Arking, D;Arnett, DK;Ashley-Koch, A;Aslibekyan, S;Assimes, T;Auer, P;Avramopoulos, D;Barnard, J;Barnes, K;Barr, RG;Barron-Casella, E;Beaty, T;Becker, D;Becker, L;Beer, R;Begum, F;Beitelshees, A;Benjamin, E;Bezerra, M;Bielak, L;Bis, J;Blackwell, T;Blangero, J;Boerwinkle, E;Borecki, I;Bowler, R;Brody, J;Broeckel, U;Broome, J;Bunting, K;Burchard, E;Cardwell, J;Carty, C;Casaburi, R;Casella, J;Chang, C;Chasman, D;Chavan, S;Chen, BJ;Chen, WM;Chen, YDI;Cho, M;Choi, SH;Chuang, LM;Chung, M;Cornell, E;Crandall, C;Crapo, J;Curran, J;Curtis, J;Custer, B;Damcott, C;Darbar, D;Das, S;David, S, .;et al. |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and analyze genotypes with four quantitative traits—plasma total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides. Common variant association yields known loci except for few variants previously poorly imputed. Rare coding variant association yields known Mendelian dyslipidemia genes but rare non-coding variant association detects no signals. A high 2M-SNP LDL-C polygenic score (top 5th percentile) confers similar effect size to a monogenic mutation (~30 mg/dl higher for each); however, among those with severe hypercholesterolemia, 23% have a high polygenic score and only 2% carry a monogenic mutation. At these sample sizes and for these phenotypes, the incremental value of WGS for discovery is limited but WGS permits simultaneous assessment of monogenic and polygenic models to severe hypercholesterolemia. |
| Date: | 2018-08-23 |
| Relation: | Nature Communications. 2018 Aug 23;9:Article number 3391. |
| Link to: | http://dx.doi.org/10.1038/s41467-018-05747-8 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000442521500016 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85052245414 |
| Appears in Collections: | [熊昭] 期刊論文
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| SCP85052245414.pdf | | 914Kb | Adobe PDF | 242 | View/Open |
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