國家衛生研究院 NHRI:Item 3990099045/11448
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 916801      線上人數 : 1510
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11448


    題名: Experimental model validation for x-ray induced luminescence imaging in tissue phantoms with europium-doped nanophosphors
    作者: Quigley, B;Cheng, SH;Souris, J;Chen, CT;Pelizzari, C;Wiersma, R;Kron, S;Lo, LW;La Riviere, P
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Objectives The goal of this study was to experimentally validate an imaging model for x-ray induced luminescence (XIL) based on the optical diffusion equation with appropriate boundary conditions. XIL imaging uses lanthanide-based nanoparticles (NPs) that emit near-infrared light in response to x-ray exposure; these NPs can potentially be used as in vivo photosensitizers or nanodosimeters. This work attempts to develop and validate an imaging model that relates observed surface radiance to NP distributions in tissue. Validation of this forward model is an important step towards solving the related inverse problem, which would allow for 3D in vivo molecular imaging with x-ray activated NPs. Methods A diffuse optical gel phantom was fabricated with 1% agar, 1% Intralipid, and 0.005% black ink to mimic to optical scattering and absorption properties of near-infrared light in tissue. Europium-doped yttrium oxide (Y2O3:Eu3+) NPs were synthesized; spectroscopy measurements exhibited an XIL emission peak at 611 nm. 2 mg of NPs were injected into the tip of a capillary tube and inserted into the phantom at 1 cm below the imaging surface. A cooled CCD camera and macro lens captured the XIL image of the surface radiance using a small animal irradiator operating at 70 kVp tube voltage. Results The luminescent point source of x-ray activated NPs at 1 cm depth produced a radially symmetric surface radiance. The signal intensity drop-off was measured with a line profile beginning at the center of the XIL signal. The proposed forward model is based on a Green’s function solution of the optical diffusion equation with extrapolated boundary conditions. When calculated for a luminescent point source a 1 cm depth in tissue with optical absorption µa=0.30 cm-1 and reduced scattering µ’s=10 cm-1 (the design parameters of the phantom), the model yielded a radial profile that agreed closely with the measured data. The approximated FWHM of the surface radiance is 1.2 cm for a point source of x-ray activated nanophosphors at 1 cm depth. Conclusions XIL surface radiance measurements were successful in an optical tissue phantom using diagnostic energy level x-rays. The proposed imaging model agreed well with the measured surface radiance. When combined with selective plane illumination, the proposed imaging model reduced to a two-dimensional convolution and thus regularized deconvolution techniques will be investigated to improve the spatial resolution of the technique.
    日期: 2016-05
    關聯: Journal of Nuclear Medicine. 2016 May;57(Suppl. 2):Meeting Abstract 1955.
    Link to: http://jnm.snmjournals.org/content/57/supplement_2/1955.abstract
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0161-5505&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000442211003113
    顯示於類別:[羅履維] 會議論文/會議摘要

    文件中的檔案:

    沒有與此文件相關的檔案.



    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋