 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12145/12927 (94%)
Visitors : 907331
Online Users : 917
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/11423
|
| Title: | Examine the relationship between maternal vitamin D supplementation during pregnancy and eczema in their offspring in a cohort study of children aged 6 years |
| Authors: | Lu, K;Huang, Y;Huang, Y;Tsai, Z;Chiu, C;Lin, C;Fang, H;Kao, P;Lee, W;Gau, C;Tsai, H;Yao, T |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Background: Vitamin D has been known for its complex roles in the immune system. Limited studies have reported the effect of maternal vitamin D supplementation during pregnancy on the development of eczema in their offspring. The objective of this study was to investigate the relationship between maternal intake of vitamin D supplements during pregnancy and eczema in their offspring at age of 6 years. Method: We included 613 children born in Chang Gung Memorial Hospital in 2010‐2011, participating in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) Cohort. Clinical data evaluated by pediatricians, epidemiologic questionnaires, and serum for measurement of allergen‐specific immunoglobulin E were collected for children aged 6 years. Atopy was defined by Phadiatop Infant. Logistic regression models with covariates adjustment were carried out to examine the association between maternal intake of vitamin D supplements during pregnancy and offspring developing physician‐diagnosed eczema later on. Results: Maternal intake of vitamin D supplements during pregnancy was associated with a higher risk of physician‐diagnosed eczema in children at 6 years of age (adjusted odds ratio [AOR]: 1.97, 95% CI: 1.24‐3.12; P = 0.004). There was also a significant relationship between current eczema and maternal intake of vitamin D supplements for more than or equal to three months during pregnancy (AOR: 2.12, 95%CI: 1.20‐3.72; P = 0.009). Physician‐diagnosed eczema was also significantly related to family history of atopic eczema, birth weight, cat exposure during pregnancy and socioeconomic status. Subgroup analyses based on atopy revealed significant association of maternal vitamin D supplementation during pregnancy with physician‐diagnosed eczema among non‐atopic children (AOR: 3.47, 95% CI: 1.42‐8.46; P = 0.006), while the association is of borderline significance among atopic children (AOR: 1.77, 95% CI: 0.98‐3.21; P = 0.059), after adjustment for relevant confounders. Conclusion: Our results suggest that maternal vitamin D supplementation during pregnancy may increase the risk of eczema in children at 6 years of age. Further studies with larger sample size is necessary to confirm this association. |
| Date: | 2018-08 |
| Relation: | Allergy. 2018 Aug;73(Suppl. 105):296. |
| Link to: | http://dx.doi.org/10.1111/all.13537 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000441690401318 |
| Appears in Collections: | [蔡慧如] 會議論文/會議摘要
|
Files in This Item:
| File |
Size | Format | |
|---|
| ISI000441690401318.pdf | 41Kb | Adobe PDF | 243 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
