國家衛生研究院 NHRI:Item 3990099045/11419

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11419

Title:	Association of preterm birth with childhood eczema: A prospective cohort study in Taiwan
Authors:	Huang, Y;Yao, T;Huang, Y;Tsai, Z;Chiu, C;Lu, K;Kao, P;Lin, C;Fang, H;Gau, C;Lee, W;Tsai, H
Contributors:	Institute of Population Health Sciences
Abstract:	Background: Previous studies assessing the relationship between preterm birth and childhood eczema have not reached a consensus yet. This study aimed to examine whether the risk of developing eczema among children in Taiwan is influenced by preterm birth. Method: This study consisted of 613 children participating in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort. The study children (age 6.3 ± 0.3 years; 345 boys, 56.3%) were born in 2010‐2011 at the Chang Gung Memorial Hospital, Taiwan. Birth information of the study subjects was obtained from medical records. Demographic, epidemiologic and clinical information were obtained from a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Atopy status was determined by Phadiatop Infant. Logistic regression analysis with covariate adjustment was performed to determine the association between preterm birth and childhood eczema. Adjusted covariates included gender, age, caesarean section, breastfeeding, parental allergic diseases, maternal education level, maternal age at birth, and maternal smoking during pregnancy. Results: No significant difference of physician‐diagnosed eczema (P = 0.88) or current eczema (P = 0.82) was observed between children born full‐term and preterm. After stratifying by atopy status, we found that children born preterm had a more than three‐fold higher risk of having physician‐diagnosed eczema (adjusted OR (AOR) = 3.92; 95% CI = 1.25‐12.29; P = 0.02) and current eczema (AOR = 3.16; 95% CI = 1.06‐9.41, P = 0.04) than their counterpart in the non‐atopic group. No statistical significance was observed for the association between preterm birth and eczema in the atopic group. No association between preterm birth and eczema was found when stratifying by gender. Conclusion: Our results reveal that non‐atopic children born preterm have a higher risk of developing eczema. The results suggest potential modifiable effect of atopy on the association between preterm birth and eczema. Further studies with a larger sample size are needed to validate the findings in this study.
Date:	2018-08
Relation:	Allergy. 2018 Aug;73(Suppl. 105):684.
Link to:	http://dx.doi.org/10.1111/all.13539
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000441690405020
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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