國家衛生研究院 NHRI:Item 3990099045/1139
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    題名: Design, synthesis, and biological evaluation of novel alkenylthiophenes as potent and selective CB1 cannabinoid receptor antagonists
    作者: Tai, CL;Hung, MS;Pawar, VD;Tseng, SL;Song, JS;Hsieh, WP;Chiu, HH;Wu, HC;Hsieh, MT;Kuo, CW;Hsieh, CC;Tsao, JP;Chao, YS;Shia, KS
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: A novel class of (5-(pent-1-enyl)thiophen-2-yl)pyrazole antagonists was discovered, many of which exhibited potent CB1 activity and good CB1/2 selectivity, suggesting that along with a 1,3-transposition of the carbonyl of the pyrazole 3-carboxamide, bioisosteric replacement of the conventional pyrazole 5-aryl group with a thienyl ring substituted with an appropriate alkenyl moiety is viable.
    關鍵詞: Chemistry, Organic
    日期: 2008-02-07
    關聯: Organic and Biomolecular Chemistry. 2008 Feb;6(3):447-450.
    Link to: http://dx.doi.org/10.1039/b716434c
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000253423400007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=38549120212
    顯示於類別:[夏克山] 期刊論文
    [趙宇生(2002-2013)] 期刊論文
    [洪明秀] 期刊論文

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