國家衛生研究院 NHRI:Item 3990099045/11369
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    题名: Calcium phosphate particles stimulate exosome secretion from phagocytes for the enhancement of drug delivery
    作者: Shyong, YJ;Chang, KC;Lin, FH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Exosomes are attractive potential carriers for drug delivery because of their natural function of transferring biomolecules among cells without eliciting immune responses. However, an obstacle to the application of exosomes for drug delivery is the difficulty in collecting sufficient numbers of these vesicles. In this study, we demonstrate treatment with calcium phosphate (CaP) particles could increase over two-fold the number of exosomes secreted from macrophage-like RAW264.7 cells and monocyte-like THP-1 cells. CaP particles were easily internalized into cells and dissolved in acidic late-endosomes or lysosomes, resulting in the rupture of their membranes followed by the release of Ca2+ into cytosol. Moreover, we found that exosomes secreted from cells treated with CaP particles are not contaminated by the Ca2+ released from CaP; the Ca2+ contents in exosomes secreted from CaP particle-treated cells were similar to that in exosomes from untreated control cells. This study highlights the potential for the efficient production of exosomes using CaP particles for drug delivery.
    日期: 2018-11
    關聯: Colloids and Surfaces B: Biointerfaces. 2018 Nov;171:391-397.
    Link to: http://dx.doi.org/10.1016/j.colsurfb.2018.07.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0927-7765&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000447575400047
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85050613827
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