國家衛生研究院 NHRI:Item 3990099045/11303

NHRI > National Institute of Environmental Health Sciences > Yue-Liang Guo > Periodical Articles > Item 3990099045/11303

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Title:	2-naphthol levels and allergic disorders in children
Authors:	Lin, TJ;Guo, YL;Hsu, JC;Wang, IJ
Contributors:	National Institute of Environmental Health Sciences
Abstract:	Background: The measurement of polycyclic aromatic hydrocarbons (PAH) in ambient air is quite difficult to perform. Using urine biomarkers of PAH such as 2-naphthol is one approach to this problem. This study explored the association between urine 2-naphthol levels and allergic diseases. The associations between 2-naphthol levels and oxidative stress biomarkers for the possible disease pathogenesis were also investigated. Method: A total of 453 kindergarten children from the (Childhood Environment and Allergic Diseases Study) CEAS cohort with urine samples were recruited. Urine 2-naphthol levels were measured by high-performance liquid chromatography mass spectrometry (HPLC-MS/MS) and markers of oxidative stress (8OHdG) were measured by enzyme-linked immunosorbent assays (ELISA). Information on environmental risk factors and allergic diseases were also collected. The association between 2-naphthol levels, 8OHdG levels, IgE, and allergic diseases were evaluated by multivariate linear regression and logistic regression. Results: Levels of 2-naphthol were positively correlated with 8OHdG levels. A one ln-unit increase in the 2-naphthol level was positively associated to 8OHdG levels (per ln-unit: β = 100.61, p < 0.001). When dividing 2-naphthol levels into quartiles, asthma was significantly associated with 2-naphthol levels at a concentration of >1.60 ng/mL (adjusted OR: 3.14, 95% CI 1.34–7.35). Conclusion: Urine 2-naphthol levels are associated with markers of oxidative stress and the risk of allergic diseases in young children.
Date:	2018-07-09
Relation:	International Journal of Environmental Research and Public Health. 2018 Jul 9;15(7):Article number 1449.
Link to:	http://dx.doi.org/10.3390/ijerph15071449
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000445543500156
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85050016177
Appears in Collections:	[Yue-Liang Guo] Periodical Articles

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