Investigation of the root extract of Antidesma pentandrum var. barbatum led to the isolation of seven new compounds, antidesmol (1), antidesmanins E (2) and F (3), antidesnone (4), antidesnol (5), barbatumols A (6) and B (7), together with 14 known compounds including sodium aristolochate-I (10) and aristolochic acid-I methyl ester (11).