國家衛生研究院 NHRI:Item 3990099045/1122
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    题名: Expedient synthesis and structure-activity relationships of phenanthroindolizidine and phenanthroquinolizidine alkaloids
    作者: Chuang, TH;Lee, SJ;Yang, CW;Wu, PL
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: The total synthesis of alkaloids phenanthroindolizidine 1a, tylophorine 1b, and phenanthroquinolizidine 1c, has been achieved in 46%, 49%, and 42% overall yield, respectively, starting from the corresponding phenanthrene-9-carboxaldehyde. Compound 1c exhibited potent inhibition activity in three human cancer cell lines, with IC50 values ranging from 104 to 130 nM. The structure-activity relations of these alkaloids and some of their synthetic intermediates against the three cell lines were also described.
    关键词: Chemistry, Organic
    日期: 2006
    關聯: Organic and Biomolecular Chemistry. 2006;4(5):860-867.
    Link to: http://dx.doi.org/10.1039/b516152e
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1477-0520&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000235992700016
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33644524990
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