國家衛生研究院 NHRI:Item 3990099045/11208
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    题名: Total synthesis of tetarimycin A, (±)-Naphthacemycin A9, and (±)-Fasamycin A: structure-activity relationship studies against drug-resistant bacteria
    作者: Huang, JK;Yang Lauderdale, TL;Lin, CC;Shia, KS
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Making use of a reductive olefin coupling reaction and Michael-Dieckmann condensation as two key operations, we have completed a concise total synthesis of tetarimycin A, (±)-naphthacemycin A9, and (±)-fasamycin A in a highly convergent and practical protocol. Synthetic procedures thus developed have also been applied to provide related analogues for structure-activity relationship studies, thereby coming to the conclusion that the free hydroxyl group at C-10 is essential for exerting inhibitory activities against a panel of Gram-positive bacteria, including drug-resistant strains VRE and MRSA.
    日期: 2018-05-22
    關聯: Journal of Organic Chemistry. 2018 May 22;83(12):6508-6523.
    Link to: http://dx.doi.org/10.1021/acs.joc.8b00802
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3263&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000445712900024
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047456786
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