國家衛生研究院 NHRI:Item 3990099045/11192
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    题名: Effects of long-term exposure to CO and PM2.5 on microalbuminuria in type 2 diabetes
    作者: Chin, WS;Chang, YK;Huang, LF;Tsui, HC;Hsu, CC;Guo, YL
    贡献者: National Institute of Environmental Health Sciences;Institute of Population Health Sciences
    摘要: OBJECTIVE: No study has examined the effects of air pollutants on albuminuria in type 2 diabetes. Therefore, the present study investigated this association. METHODS: This follow-up study enrolled 812 patients with type 2 diabetes between 2003 and 2012. The urinary albumin-to-creatinine ratio (ACR) was recorded annually. Exposure to the air pollutants CO, NO2, O3, SO2, and PM2.5 was interpolated from 72 air-quality monitoring stations to residences by using the kriging method. The association between air pollutants and ACR increase was assessed using mixed-effect model with random intercepts for 36 clinics. RESULTS: The study objects (mean age: 55.4 years) were followed for 3 or more years (average period: 5.4 years). ACR increase was found to be positively associated with the male sex, baseline hemoglobin A1c, and exposure to CO and PM2.5, and negatively associated with waist circumference through multiple linear regression. Annually urine albumin/creatinine ratio increase was estimated by the final model, Patients exposed to higher levels of CO (e.g., third quartile, 1025ppb) and lower levels of CO (e.g., first quartile, 850ppb) had an annual ACR increase of 3.73 and 3.54mg/g, respectively. Patients exposed to higher levels of PM2.5 (e.g., third quartile, 38.8mug/M3) and lower levels of PM2.5 (e.g., first quartile, 27.7mug/M3) had an annual ACR increase of 3.96 and 3.17mg/g, respectively. CONCLUSIONS: Exposure to high CO and PM2.5 levels increased albuminuria in type 2 diabetes.
    日期: 2018-05
    關聯: International Journal of Hygiene and Environmental Health. 2018 May;221(4):602-608.
    Link to: http://dx.doi.org/10.1016/j.ijheh.2018.04.009
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1438-4639&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000440394200002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85046151834
    显示于类别:[郭育良] 期刊論文
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