| Abstract: | Four new coumarinolignans, antidesmanin A (=7-(1,1-dimethylallyl)-2,3-dihydro-3-(4-hydroxy-3,5-dimethoxvphenyl)-10-methoxy-2-methyl-6H-1,4,5-trioxaphenanthren-6-one; 1), antidesmanin B (=3,7-bis(1,1-dimethylallyl)-2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one; 2), antidesmanin C (=2,7-bis-(1,1-dimethylallyl)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one; 3) and antidesmanin D (=2-(3,4-dihydroxyphenyl)-3,7-bis(1,1-dimethylallyl)2,3-dihydroxy-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one or 3-(3,4-dihydroxyphenyl)-2,7-bis(1,1-dimethylallyl)-2,3-dihydro-10-methoxy-6H-1,4,5-trioxaphenanthren-6-one; 4) have been isolated from the root of the Formosan Antidesma pentandrum var. barbatum. The structures of these new compounds were elucidated by spectroscopic data. Compounds 1-3 exhibited marginal cytotoxicity against MCF-7 (breast) and SF-268 (CNS) cancer cell lines in vitro. |
