國家衛生研究院 NHRI:Item 3990099045/11143
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 858714      Online Users : 726
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11143


    Title: Molecular regulation of bone metastasis pathogenesis
    Authors: Wu, MY;Li, CJ;Yiang, GT;Cheng, YL;Tsai, AP;Hou, YT;Ho, YC;Hou, MF;Chu, PY
    Contributors: National Institute of Cancer Research
    Abstract: Distant metastases are the major cause of mortality in cancer patients. Bone metastases may cause bone fractures, local pain, hypercalcemia, bone marrow aplasia, and spinal cord compression. Therefore, the management of bone metastases is important in cancer treatment. Normal bone remodeling is regulated by osteoprotegerin ligand (OPGL), receptor activator of NF-kappaB ligand (RANKL), parathyroid hormone-related protein (PTHrP), and other cytokines. In the tumor microenvironment, tumor cells induce a vicious cycle that promotes osteoblastic and osteolytic lesions. Studies support the idea that distant metastases may occur due to the immunosuppressive function of myeloid-derived suppressor cells (MDSCs). These cells inhibit T cells and natural killer (NK) cells and differentiate into tumor-associating macrophages (TAMs), monocytes, and dendritic cells (DCs). In this review, we summarize studies focusing on the role of MDSCs in bone metastasis and provide a strong foundation for developing anticancer immune treatments and anticancer therapies, in general.
    Date: 2018-04-18
    Relation: Cellular Physiology and Biochemistry. 2018 Apr 18;46(4):1423-1438.
    Link to: http://dx.doi.org/10.1159/000489184
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000433152000010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047768479
    Appears in Collections:[Others] Periodical Articles

    Files in This Item:

    File SizeFormat
    PUB29689559.pdf2623KbAdobe PDF173View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback