國家衛生研究院 NHRI:Item 3990099045/11123
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    題名: The role of MTHFR genotype in colorectal cancer susceptibility in Taiwan
    作者: Lin, KM;Yang, MD;Tsai, CW;Chang, WS;Hsiao, CL;Jeng, LB;Yueh, TC;Lee, MC;Bau, DT
    貢獻者: Institute of Population Health Sciences
    摘要: Aim: To evaluate the contribution of methyl-enetetrahydrofolate reductase (MTHFR) genotype to the risk of colorectal cancer (CRC) in Taiwan. Materials and Methods: In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age-and gender-matched healthy individuals. Results: The percentages of CC, CT and TT genotypes for MTHFR rs1801133 were 64.1%, 29.8% and 6.1% in the CRC group and 51.1%, 37.0% and 11.9% in the control group, respectively (p for trend=0.0006). Analysis of the allelic frequency distribution showed that the variant T allele of MTHFR rs1801133 conferred a lower CRC susceptibility than did the wild-type C allele (odds ratio(OR)=0.66, 95% confidence interval(CI)=0.52-0.84, p=4.32x10-5). For the gene-lifestyle interaction, there were obvious protective effects of MTHFR rs1801133 T allele on the risk of CRC among non-smokers, ever smokers and non-alcohol drinkers, but not drinkers. Conclusion: MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings.
    日期: 2018-04
    關聯: Anticancer Research. 2018 Apr;38(4):2001-2006.
    Link to: http://dx.doi.org/10.21873/anticanres.12438
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000428798000016
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85045203983
    顯示於類別:[李孟智] 期刊論文

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