國家衛生研究院 NHRI:Item 3990099045/11065
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    题名: Quantification of urinary tryptophan metabolites and evaluation of their potential use as urothelial cancer biomarkers
    作者: Li, LA;Luo, HL;Wang, CJ;Chiang, PH;Chiang, PH
    贡献者: National Institute of Environmental Health Sciences;Institute of Population Health Sciences
    摘要: Patients with chronic kidney disease or renal insufficiency have increased risk of urothelial cancer. Increased excretion of tryptophan metabolites in the urine has been observed in renal-insufficient rats. Aberrant tryptophan metabolism may play a role in the development of urothelial cancer. To evaluate the relevance of tryptophan metabolism in urothelial cancer, we developed a LC-MS-MS method to simultaneously quantify five tryptophan metabolites as well as tryptophan in urine. Urine samples were cleaned up by on-line solid phase extraction before separation by C18-amide reversed-phase chromatography. The analytes were detected in positive ion multiple reaction monitoring (MRM) mode with a lower limit of quantification at 1 ng/ml. The relative standard deviation (RSD) for recovery and precision ranged between 3.10–7.65% and 1.80–9.33%, respectively. A preliminary study on 45 upper urinary tract cancer patients and 35 controls showed that cancer patients had higher levels of kynurenine and kynurenic acid in urine and elevated urinary kynurenine/tryptophan ratios. Although further studies are needed, our preliminary data suggest that tryptophan metabolites can be potential biomarkers for diagnosis and prognosis of urothelial cancer.
    日期: 2017-10
    關聯: Toxicology Letters. 2017 Oct;280:S299.
    Link to: http://dx.doi.org/10.1016/j.toxlet.2017.07.836
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0378-4274&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000425486700759
    显示于类别:[李立安] 會議論文/會議摘要
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