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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/11034
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| Title: | Anti-herpetic medications and reduced risk of dementia in patients with herpes simplex virus infections-a nationwide, population-based cohort study in Taiwan |
| Authors: | Tzeng, NS;Chung, CH;Lin, FH;Chiang, CP;Yeh, CB;Huang, SY;Lu, RB;Chang, HA;Kao, YC;Yeh, HW;Chiang, WS;Chou, YC;Tsao, CH;Wu, YF;Chien, WC |
| Contributors: | Center for Neuropsychiatric Research |
| Abstract: | This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan's National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000. A multivariable Cox proportional hazards regression model was used to evaluate the risk of developing dementia in the HSV cohort. This analysis revealed an adjusted hazard ratio of 2.564 (95% CI: 2.351-2.795, P < 0.001) for the development of dementia in the HSV-infected cohort relative to the non-HSV cohort. Thus, patients with HSV infections may have a 2.56-fold increased risk of developing dementia. A risk reduction of dementia development in patients affected by HSV infections was found upon treatment with anti-herpetic medications (adjusted HR = 0.092 [95% CI 0.079-0.108], P < 0.001). The usage of anti-herpetic medications in the treatment of HSV infections was associated with a decreased risk of dementia. These findings could be a signal to clinicians caring for patients with HSV infections. Further research is, therefore, necessary to explore the underlying mechanism(s) of these associations. |
| Date: | 2018-04 |
| Relation: | Neurotherapeutics. 2018 Apr;15(2):417-429. |
| Link to: | http://dx.doi.org/10.1007/s13311-018-0611-x |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1933-7213&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000431510200015 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85042592986 |
| Appears in Collections: | [其他] 期刊論文
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| PUB29488144.pdf | | 627Kb | Adobe PDF | 479 | View/Open |
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