國家衛生研究院 NHRI:Item 3990099045/10948
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 973830      線上人數 : 1075
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10948


    題名: Metformin is associated with decreased skin cancer risk in Taiwanese patients with type 2 diabetes
    作者: Tseng, CH
    貢獻者: National Institute of Environmental Health Sciences
    摘要: BACKGROUND: Metformin, an antidiabetic drug, is associated with decreased cancer risk, but its effect on skin cancer is unknown. OBJECTIVE: To evaluate skin cancer risk associated with metformin use. METHODS: Matched pairs of 16237 ever and never metformin users were retrospectively enrolled from patients with new-onset type 2 diabetes diagnosed between 1999 and 2005 from Taiwan's National Health Insurance database, and followed until December 31, 2011. Hazard ratios (HRs) were estimated using Cox regression weighted for propensity scores. RESULTS: Skin cancer incidence was 45.59 and 83.90 per 100,000 person-years in ever and never users, respectively (HR 0.540, 95% confidence interval: 0.357-0.819). In ever users, the HRs (95% confidence intervals) for the first (<21.00 months), second (21.00-45.83 months), and third (>45.83 months) cumulative duration tertiles were 0.817 (0.448-1.489), 0.844 (0.504-1.412), and 0.114 (0.036-0.364), respectively; and 1.006 (0.579-1.748), 0.578 (0.317-1.051), and 0.229 (0.099-0.530), respectively, for the first, second, and third cumulative dose tertiles. HRs were 0.523 (0.175-1.562) for melanoma and 0.496 (0.319-0.772) for non-melanoma skin cancer. LIMITATIONS: Few patients with skin cancer and lack of information on ultraviolet exposure and tumor histopathology. CONCLUSION: Metformin use is associated with decreased skin cancer risk.
    日期: 2018-04
    關聯: Journal of the American Academy of Dermatology. 2018 Apr;78(4):694-700.
    Link to: http://dx.doi.org/10.1016/j.jaad.2017.12.016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0190-9622&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000427404200013
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85041694703
    顯示於類別:[其他] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB29246826.pdf444KbAdobe PDF296檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋