國家衛生研究院 NHRI:Item 3990099045/10909
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10909


    Title: Radiation-sensitive dendrimer-based drug delivery system
    Authors: Wu, SY;Chou, HY;Yuh, CH;Mekuria, SL;Kao, YC;Tsai, HC
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off-target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l-cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ-radiation. Presence of γ-radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation-sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l-cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.
    Date: 2018-02
    Relation: Advanced Science. 2018 Feb;5(2):Article number 1700339.
    Link to: http://dx.doi.org/10.1002/advs.201700339
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2198-3844&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000426200000020
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85037360446
    Appears in Collections:[Chiou-Hwa Yuh] Periodical Articles

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