國家衛生研究院 NHRI:Item 3990099045/10907
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10907


    Title: Development of circumventricular organs in the mirror of zebrafish enhancer-trap transgenics
    Authors: Garcia-Lecea, M;Gasanov, E;Jedrychowska, J;Kondrychyn, I;Teh, C;You, MS;Korzh, V
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: The circumventricular organs (CVOs) are small structures lining the cavities of brain ventricular system. They are associated with the semitransparent regions of the blood-brain barrier (BBB). Hence it is thought that CVOs mediate biochemical signaling and cell exchange between the brain and systemic blood. Their classification is still controversial and development not fully understood largely due to an absence of tissue-specific molecular markers. In a search for molecular determinants of CVOs we studied the green fluorescent protein (GFP) expression pattern in several zebrafish enhancer trap transgenics including Gateways (ET33-E20) that has been instrumental in defining the development of choroid plexus. In Gateways the GFP is expressed in regions of the developing brain outside the choroid plexus, which remain to be characterized. The neuroanatomical and histological analysis suggested that some previously unassigned domains of GFP expression may correspond to at least six other CVOs-the organum vasculosum laminae terminalis (OVLT), subfornical organ (SFO), paraventricular organ (PVO), pineal (epiphysis), area postrema (AP) andmedian eminence (ME). Two other CVOs, parapineal and subcommissural organ (SCO) were detected in other enhancer-trap transgenics. Hence enhancer-trap transgenic lines could be instrumental for developmental studies of CVOs in zebrafish and understanding of the molecular mechanism of disease such a hydrocephalus in human. Their future analysis may shed light on general and specific molecular mechanisms that regulate development of CVOs.
    Date: 2017-12
    Relation: Frontiers in Neuroanatomy. 2017 Dec;11:Article number 114.
    Link to: http://dx.doi.org/10.3389/fnana.2017.00114
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1662-5129&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000417254800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85043766180
    Appears in Collections:[Others] Periodical Articles

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