國家衛生研究院 NHRI:Item 3990099045/10868
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    题名: miRTarBase update 2018: A resource for experimentally validated microRNA-target interactions
    作者: Chou, CH;Shrestha, S;Yang, CD;Chang, NW;Lin, YL;Liao, KW;Huang, WC;Sun, TH;Tu, SJ;Lee, WH;Chiew, MY;Tai, CS;Wei, TY;Tsai, TR;Huang, HT;Wang, CY;Wu, HY;Ho, SY;Chen, PR;Chuang, CH;Hsieh, PJ;Wu, YS;Chen, WL;Li, MJ;Wu, YC;Huang, XY;Ng, FL;Buddhakosai, W;Huang, PC;Lan, KC;Huang, CY;Weng, SL;Cheng, YN;Liang, C;Hsu, WL;Huang, HD
    贡献者: Institute of Population Health Sciences
    摘要: MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides that are involved in negative regulation of mRNA at the post-transcriptional level. Previously, we developed miRTarBase which provides information about experimentally validated miRNA-target interactions (MTIs). Here, we describe an updated database containing 422 517 curated MTIs from 4076 miRNAs and 23 054 target genes collected from over 8500 articles. The number of MTIs curated by strong evidence has increased approximately 1.4-fold since the last update in 2016. In this updated version, target sites validated by reporter assay that are available in the literature can be downloaded. The target site sequence can extract new features for analysis via a machine learning approach which can help to evaluate the performance of miRNA-target prediction tools. Furthermore, different ways of browsing enhance user browsing specific MTIs. With these improvements, miRTarBase serves as more comprehensively annotated, experimentally validated miRNA-target interactions databases in the field of miRNA related research. miRTarBase is available at http://miRTarBase.mbc.nctu.edu.tw/.
    日期: 2018-01
    關聯: Nucleic Acids Research. 2018 Jan;46(D1):D296-D302.
    Link to: http://dx.doi.org/10.1093/nar/gkx1067
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0305-1048&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000419550700045
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85040945128
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