Prostate cancer (PCa) ranks the 5th most common cancer in the world. Receptor tyrosine-kinase like orphan receptor 2 (ROR2) is a regulator of non-canonical Wnt signaling. Expression of mRNA and protein of ROR2 was analyzed in clinical samples with qRT-PCR and IHC staining. Tranwell assays and wound healing assay were performed to determine the roles of ROR2 on migration and invasion of PCa cells. Micro-Western Array MWA platform was introduced to determine downstream signaling network regulated by ROR2. Analysis of ROR2 gene expression level in a total of 249 normal prostate tissues, benign prostate hyperplasia BPH, and prostate tumors revealed that ROR2 mRNA level is the lowest in metastatic PCa. IHC staining analysis of 48 PCa tissues indicated that ROR2 expression inversely correlated to aggressiveness of PCa....
Date:
2017-10
Relation:
Annals of Oncology. 2017 Oct;28(Suppl. 9):Meeting Abstract P1-284.
