國家衛生研究院 NHRI:Item 3990099045/10862
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10862


    Title: A graphene-polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells
    Authors: Huang, CT;Shrestha, LK;Ariga, K;Hsu, SH
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: 3D bioprinting is known as an additive manufacturing technology that builds customized structures from cells and supporting biocompatible materials for the repair of damaged tissues or organs. In this study, we prepared water-dispersible graphene and graphene oxide, which are 2D nanomaterials with high conductivity and potential applications in neural tissue engineering. Moreover, we synthesized a new biodegradable waterborne polyurethane with soft segments that mostly contained poly(epsilon-caprolactone) (2 kDa) and 20 mol% of shorter (1.5 kDa) poly(D, L-lactide) chains. This polyurethane dispersion at a solid content of 25% in a cell culture medium underwent a sol-gel transition near human body temperature with a suitable gel modulus. After this, we mixed graphene or graphene oxide with polyurethane to prepare a graphene-based nanocomposite hydrogel for neural stem cell (NSC) printing. The rheological properties of the graphene-based nanocomposite hydrogel were suitable for the printing and survival of NSCs. Furthermore, the addition of a very low content (25 ppm) of graphene nanomaterials to the hydrogel significantly enhanced the oxygen metabolism (2- to 4-fold increase) as well as the neural differentiation of NSCs. In summary, the graphene-polyurethane nanocomposite hydrogel may be a possible bioink for printing 3D cell-laden tissue constructs for neural tissue engineering.
    Date: 2017-11
    Relation: Journal of Materials Chemistry B. 2017 Nov;5(44):8854-8864.
    Link to: http://dx.doi.org/10.1039/c7tb01594a
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000415354000023
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85034217206
    Appears in Collections:[Shan-Hui Hsu] Periodical Articles

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