國家衛生研究院 NHRI:Item 3990099045/10851
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    题名: Fc epsilon RI gamma-chain negatively modulates dectin-1 responses in dendritic cells
    其它题名: Fcεri γ-chain negatively modulates dectin-1 responses in dendritic cells
    作者: Pan, YG;Yu, YL;Lin, CC;Lanier, LL;Chu, CL
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: The inhibitory effect of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapters DAP12 and Fc epsilon RI gamma-chain (FcR gamma) has been found in many immune functions. Herein, we have further explored the role of these adapters in C-type lectin receptors response. We identified that FcR gamma, but not DAP12, could negatively regulate the Dectin-1 responses in dendritic cells (DCs). Loss of FcR gamma or both DAP12 and FcR gamma enhanced the maturation and cytokine production in DCs upon Dectin-1 activation compared to normal cells, whereas DCs lacking only DAP12 showed little changes. In addition, increments of T cell activation and T helper 17 polarization induced by FcR gamma-deficient DCs were observed both in vitro and in vivo. Examining the Dectin-1 signaling, we revealed that the activations of several signaling molecules were augmented in FcR gamma-deficient DCs stimulated with Dectin-1 ligands. Furthermore, we demonstrated that the association of phosphatases SHP-1 and PTEN with FcR gamma may contribute to the negative regulation of FcR gamma in Dectin-1 activation in DCs. These results extend the inhibitory effect of ITAM-containing adapters to Dectin-1 response in immune functions, even though Dectin-1 contains an ITAM-like intracellular domain. According to the role of Dectin-1 in responding to microbes and tumor cells, our finding may have applications in the development of vaccine and cancer therapy.
    日期: 2017-10-27
    關聯: Frontiers in Immunology. 2017 Oct 27;8:Article number 1424.
    Link to: http://dx.doi.org/10.3389/fimmu.2017.01424
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000413832500001
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85032216783
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