國家衛生研究院 NHRI:Item 3990099045/10848
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    题名: Comparative transcriptomic characterization of a new mib mutant allele, mibnn2002, in zebrafish
    作者: Lai, KP;Li, JW;Hsu, CH;You, MS;Chan, TF;Tse, WKF;Jiang, YJ
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: mibnn2002, identified from an allele screen, shows early segmentation defect and severe cell death phenotypes, which are different from those of other described mib mutant alleles. We have previously reported its defects in somitogenesis and identified its origin of mutation, a large deletion in LG2. The report here is a continuous study, where we applied the bioinformatics analysis to profile the genetic background of mibnn2002 mutants. By comparing the transcriptomic data of mibnn2002 mutants with those of AB wild-type, a total of 1945 differentially expressed genes were identified, including 685 up- and 1260 down-regulated genes. The Database for Annotation, Visualization and Integrated Discovery (DAVID) analysis and Ingenuity Pathway Analysis (IPA) identified the enriched pathways and their related biological functions. Our data further demonstrated that the defects in the somitogenesis were related to the down-regulated segmentation genes, such as foxc1a, smyhc1, myod1 and mylpfa.
    日期: 2018-02
    關聯: Gene. 2018 Feb;642:51-57.
    Link to: http://dx.doi.org/10.1016/j.gene.2017.11.016
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0378-1119&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000423892700007
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85033462802
    显示于类别:[江運金] 期刊論文

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