國家衛生研究院 NHRI:Item 3990099045/10789

NHRI > Institute of Biomedical Engineering and Nanomedicine > Jen-Kun Chen > Periodical Articles > Item 3990099045/10789

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10789

Title:	Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice
Authors:	Bai, KJ;Chuang, KJ;Chen, JK;Hua, HE;Shen, YL;Liao, WN;Lee, CH;Chen, KY;Lee, KY;Hsiao, TC;Pan, CH;Ho, KF;Chuang, HC
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	We investigated the effects of nickel oxide nanoparticles (NiONPs) on the pulmonary inflammopathology. NiONPs were intratracheally installed into mice, and lung injury and inflammation were evaluated between 1 and 28 d. NiONPs caused significant increases in LDH, total protein, and IL-6 and a decrease in IL-10 in the BALF and increases in 8-OHdG and caspase-3 in lung tissues at 24h. Airway inflammation was present in a dose-dependent manner from the upper to lower airways at 24h of exposure as analyzed by SPECT. Lung parenchyma inflammation and small airway inflammation were observed by CT after NiONP exposure. 8-OHdG in lung tissues had increased with formation of fibrosis at 28 d. Focal adhesion was the most important pathways identified at 24h as determined by protemics, whereas glutathione metabolism was the most important identified at 28 d. Our results demonstrated the pulmonary inflammopathology caused by NiONPs based on image-to-biochemical approaches.
Date:	2018-10
Relation:	Nanomedicine: Nanotechnology, Biology, and Medicine. 2018 Oct; 14(7):2329-2339.
Link to:	http://dx.doi.org/10.1016/j.nano.2017.10.003
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1549-9634&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000446496900032
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85035119944
Appears in Collections:	[Jen-Kun Chen] Periodical Articles

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