國家衛生研究院 NHRI:Item 3990099045/10785

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chia-Wen Wu > Periodical Articles > Item 3990099045/10785

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10785

Title:	Enhanced charge collection in MOF-525-PEDOT nanotube composites enable highly sensitive biosensing
Authors:	Huang, TY;Kung, CW;Liao, YT;Kao, SY;Cheng, M;Chang, TH;Henzie, J;Alamri, HR;Alothman, ZA;Yamauchi, Y;Ho, KC;Wu, KCW
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	With the aim of a reliable biosensing exhibiting enhanced sensitivity and selectivity, this study demonstrates a dopamine (DA) sensor composed of conductive poly(3,4-ethylenedioxythiophene) nanotubes (PEDOT NTs) conformally coated with porphyrin-based metal-organic framework nanocrystals (MOF-525). The MOF-525 serves as an electrocatalytic surface, while the PEDOT NTs act as a charge collector to rapidly transport the electron from MOF nanocrystals. Bundles of these particles form a conductive interpenetrating network film that together: (i) improves charge transport pathways between the MOF-525 regions and (ii) increases the electrochemical active sites of the film. The electrocatalytic response is measured by cyclic voltammetry and differential pulse voltammetry techniques, where the linear concentration range of DA detection is estimated to be 2 × 10-6-270 × 10-6m and the detection limit is estimated to be 0.04 × 10-6m with high selectivity toward DA. Additionally, a real-time determination of DA released from living rat pheochromocytoma cells is realized. The combination of MOF5-25 and PEDOT NTs creates a new generation of porous electrodes for highly efficient electrochemical biosensing.
Date:	2017-11
Relation:	Advanced Science. 2017 Nov;4(11):Article number 1700261.
Link to:	http://dx.doi.org/10.1002/advs.201700261
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2198-3844&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000416155900022
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85030220157
Appears in Collections:	[Chia-Wen Wu] Periodical Articles

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