國家衛生研究院 NHRI:Item 3990099045/10777
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10777


    Title: Upregulation of CISD2 augments ROS homeostasis and contributes to tumorigenesis and poor prognosis of lung adenocarcinoma
    Authors: Li, SM;Chen, CH;Chen, YW;Yen, YC;Fang, WT;Tsai, FY;Chang, JL;Shen, YY;Huang, SF;Chuu, CP;Chang, IS;Hsiung, CA;Jiang, SS
    Contributors: Institute of Population Health Sciences;National Institute of Cancer Research;Pathology Core Laboratory;Institute of Molecular and Genomic Medicine;Institute of Cellular and Systems Medicine
    Abstract: CISD2 is a redox-sensitive gene critical for normal development and mitochondrial integrity. CISD2 was known to have aberrant expression in several types of human cancers. However, its relation with lung cancer is still not clear. In this study we found CISD2 mRNA was significantly upregulated in lung adenocarcinoma (ADC) samples, compared with their adjacent normal counterparts, and was correlated with tumor stage, grade, and prognosis based on analysis of clinical specimens-derived expression data in public domain and our validation assay. Cell based assay indicated that CISD2 expression regulated accumulation of reactive oxygen species (ROS), polarization of mitochondrial membrane potential, as well as cell viability, apoptosis, invasiveness, and tumorigenicity. In addition, CISD2 expression was found significantly correlated with stress response/redox signaling genes such as EGR1 and GPX3, while such correlations were also found valid in many public domain data. Taken together, upregulation of CISD2 is involved in an increased antioxidant capacity in response to elevated ROS levels during the formation and progression of lung ADC. The molecular mechanism underlying how CISD2 regulates ROS homeostasis and augments malignancy of lung cancer warrants further investigations.
    Date: 2017-09-19
    Relation: Scientific Reports. 2017 Sep 19;7:Article number 11893.
    Link to: http://dx.doi.org/10.1038/s41598-017-12131-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000411165100070
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85029830796
    Appears in Collections:[Chao A. Hsiung] Periodical Articles
    [Shih-Sheng Jiang] Periodical Articles
    [I-Shou Chang] Periodical Articles
    [Ya-Wen Chen] Periodical Articles
    [Ying-ying Shen] Periodical Articles
    [Shiu-Feng Kathy Huang] Periodical Articles
    [Chih-Pin Chuu] Periodical Articles

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