國家衛生研究院 NHRI:Item 3990099045/10732
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    題名: Control of NF-kappa B activity, inflammation and stemness properties in cancer cells by Copper Metabolism (Murr1) Domain-Containing 1
    其他題名: Control of NF-κB activity, inflammation and stemness properties in cancer cells by Copper Metabolism (Murr1) Domain-Containing 1
    作者: Yeh, DW;Lai, CY;Liu, YL;Lu, CH;Chuang, TH
    貢獻者: Immunology Research Center
    摘要: It has been shown that persistant activation of NF-κB in cancer cells contributes to inflammation, expansion of tumor-initiating cancer stem-like cells (CSCs), and tumor progression. In contrast, NF-κB activation in CSCs can elevate expression and release of pro-inflammatory mediators into the tumor microenvironment and further increase stemness and inflammatory conditions in cancer cells. Nevertheless, the underlying molecular controls are still ill-defined. In this study, we used bioinformatic analysis to show the upregulation of NF-kB-target pro-inflammatory gene and downregulation of Copper Metabolism (Murr1) Domain-containing 1 (COMMD1) during the enrichment of stemness of SAS, an oral cancer cell line in tumor sphere culture. The 3′-UTR of COMMD1 mRNA consists of miR-205 target site. Parallel studies with SAS and non–small-cell lung cancer cells, H460 and D121 indicated that miR-205 reduces COMMD1 expression and the expression of miR-205 was upregulated upon NF-kB activation. COMMD1 effectively restrained inflammatory stimuli-induced NF-κB activation, cytokine production, as well as leukocytes migration. The lentiviral shRNA-mediated knockdown of COMMD1 increased the expression of stemness genes, sphere-forming capacity, and potential for anchorage-independent growth in cancer cells. Moreover, study with cancer animal model showed that COMMD1 knockdown enhances tumorigenesis and tumor growth, as well as expanded population of CD11b+ tumor-associated leukocytes and CD117+ stemness-enriched cancer cells. These results suggest that the miR-205-COMMD1-NF-κB axis forming a positive feedback loop for amplifying inflammatory and stemness-associated properties of cancer cells that further promote pro-inflammatory tumor microenvironment.
    日期: 2016-04
    關聯: The FASEB Journal. 2016 Apr;30(1, Suppl.):Meeting Abstract lb441.
    Link to: http://www.fasebj.org/content/30/1_Supplement/lb441.short
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0892-6638&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000406444005197
    顯示於類別:[莊宗顯] 會議論文/會議摘要

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