國家衛生研究院 NHRI:Item 3990099045/10730
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 915446      Online Users : 1309
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10730


    Title: Sensory axonal dysfunction in the painful diabetic polyneuropathy
    Authors: Chang, TS;Lin, CS;Tani, J;Sung, JY
    Contributors: NHRI Graduate Student Program
    Abstract: Diabetes neuropathy is a common complication of diabetes, and neuropathic pain has a detrimental impact on qualityoflife.Thisstudyinvestigatedsensorynerveexcitability properties to elucidate the axonal changes of diabetic neuropathy. A total of 95 diabetes patients (93 type II, and 2 type I) were enrolled in this study. Clinical assessment, nerve conduction studies, and nerve excitability testing data were analyzed to determine axonal dysfunction in diabetic neuropathy. Among those patients, seventeen subjects had complained of spontaneous painful sensation over feet or hands (painful cohort), and seventy-eight patients had no sensory symptoms or decreased the sensation over foot (non-painful cohort). Sensory nerve excitability of the painful cohort showed reduced late subexcitability (P=0.01), increased superexcitability (P=0.03) in compared to the non-painful cohort. There is no difference in disease duration, blood glucose levels (HbA1c) between these two cohorts. These findings suggested the possible pathogenesis of painful sensory axons might be hyperpolarized or slow potassium channels dysfunction. These insights our further understanding of painful diabetic neuropathy, and may provide a basis for neuroprotective or therapeutic approaches for painful polyneuropathy.
    Date: 2017-09
    Relation: Journal of the Peripheral Nervous System. 2017 Sep;22(3):258.
    Link to: http://dx.doi.org/10.1111/jns.12225
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1085-9489&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000409243500083
    Appears in Collections:[Others] Conference Papers/Meeting Abstract

    Files in This Item:

    File Description SizeFormat
    ISI000409243500083.pdf48KbAdobe PDF302View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback