國家衛生研究院 NHRI:Item 3990099045/10729
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 911358      在线人数 : 922
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/10729


    题名: Different axonal dysfunction pattern in seropositive and seronegative sjogren's syndrome
    作者: Tani, J;Liao, HT;Hsu, HC;Chen, LF;Lin, CSY;Chang, TS;Sung, JY
    贡献者: NHRI Graduate Student Program
    摘要: Sjögren’s syndrome (SS) is an autoimmune disease that affects both East and West. Nevertheless, we still have limited knowledge of how autoantibodies in SS affects the peripheral nervous system. In this study, we investigated the peripheral neuropathy in SS and sicca complex using the nerve excitability test, to elucidate how peripheral nerves are affected. We have enrolled a total of 22 patients with SS or sicca complex. Of these, two patients were excluded due to co-morbid carpal tunnel syndrome. Each patient received clinical evaluation, examination for SSA/SSB antibodies titer, the nerve excitability test, conventional thermal quantitative sensory test ,and conventional nerve conduction study. Compared to 33 normal control subjects, motor nerve excitability test of SS patients with positive SSA or SSB antibodies (n = 14) were found to have increased rheobase (P < 0.05), increased relative refractory period(RRP)(P < 0.01),increased refractoriness at 2.5 ms (P < 0.01), increased accommodation toward depolarizing current in threshold electrotonus (TE) (P < 0.05), and decreased super excitability (P < 0.05). The sensory axonal study in seropositive SS also revealed increased RRP (P < 0.01), increased refractoriness at 2.5 ms (P < 0.01), and increased accommodation toward hyperpolarizing current in threshold electrotonus (TE) (P < 0.05). Meanwhile, in seronegative SS and sicca complex (n = 6), we found no significant axonal properties changes. The present study revealed that peripheral nerves are affected differently in seropositive SS and in seronegative SS/sicca complex. In seropositive SS, motor axons tended to be depolarized, and both sensory and motor axons have increased refractoriness. The findings suggested that SSA and SSB antibodies might play a role in the inactivation of transient sodium channels. The effects of the antibodies on transient sodium channels might be the basis of peripheral neuropathies and even cardiac arrhythmias and heart block in SS.
    日期: 2017-09
    關聯: Journal of the Peripheral Nervous System. 2017 Sep;22(3):393.
    Link to: http://dx.doi.org/10.1111/jns.12225
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1085-9489&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000409243500418
    显示于类别:[其他] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000409243500418.pdf49KbAdobe PDF577检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈