國家衛生研究院 NHRI:Item 3990099045/10708
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10708


    Title: Increased beta-catenin accumulation and nuclear translocation are associated with concentric hypertrophy in cardiomyocytes
    Other Titles: Increased β-catenin accumulation and nuclear translocation are associated with concentric hypertrophy in cardiomyocytes
    Authors: Lee, CY;Kuo, WW;Baskaran, R;Day, CH;Pai, PY;Lai, CH;Chen, YF;Chen, RJ;Padma, VV;Huang, CY
    Contributors: National Institute of Cancer Research
    Abstract: Defective Wnt/β-Catenin signaling, activated under various pathological conditions, can result in cardiac and vascular abnormalities. In the present study, the possible role of β-catenin over expression during cardiac hypertrophy was investigated. Ten samples from hearts of human patients with acute infarction, and granulation tissue from 20 patients and 10 from normal ones were collected in order to investigate roles of β-catenin in cardiac hypertrophy. H9c2 cardiomyoblast cells and Wistar rat primary neonatal cardiomyocytes were overexpressed with β-catenin. Expression levels of β-catenin protein were increased in human acute infarction tissues and rat hypertension heart tissues. Overexpression of this transcription factor induced actin filament formation and increased hypertrophic marker protein levels via MAPK pathway. In addition, β-catenin overexpression also resulted in increased elevation of NFATc3 and p-GATA4. Therefore, acute infarction resulted in β-catenin overexpression mediated hypertrophy in cardiomyocytes regulated through MAPK pathway.
    Date: 2017-11
    Relation: Cardiovascular Pathology. 2017 Nov-Dec;31:9-16.
    Link to: http://dx.doi.org/10.1016/j.carpath.2017.07.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1054-8807&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000415656100003
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85026895554
    Appears in Collections:[Others] Periodical Articles

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