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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/10699
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| Title: | ALDH2 modulated changes in cytokine levels and cognitive function in bipolar disorder: A 12-week follow-up study |
| Authors: | Lee, SY;Wang, TY;Chen, SL;Chang, YH;Chen, PS;Huang, SY;Tzeng, NS;Wang, LJ;Lee, IH;Chen, KC;Yang, YK;Yang, YH;Chen, CS;Lu, RB |
| Contributors: | Center for Neuropsychiatric Research |
| Abstract: | OBJECTIVES: We investigated the association of the aldehyde dehydrogenase 2 ( ALDH2) polymorphism (rs671), which is involved with the dopaminergic function, and with changes in cytokine levels and cognitive function, in a 12-week follow-up study in patients with bipolar disorder. METHODS: Patients with a first diagnosis of bipolar disorder were recruited. Symptom severity and levels of plasma cytokines (tumor necrosis factor alpha, C-reactive protein, interleukin 6 and transforming growth factor beta1) were examined during weeks 0, 1, 2, 4, 8 and 12. Neurocognitive function was evaluated at baseline and endpoint. The ALDH2 polymorphism genotype was determined. RESULTS: A total of 541 patients with bipolar disorder were recruited, and 355 (65.6%) completed the 12-week follow-up. A multiple linear regression analysis showed a significant ( p = 0.000226) association between the ALDH2 polymorphism and changes in C-reactive protein levels. Different aspects of cognitive function improved in patients with different ALDH2 genotypes. Only patients with the ALDH2*1*1 genotype showed significant correlations between improvement of cognitive function and increased transforming growth factor -beta1. CONCLUSION: The ALDH2 gene might influence changes in cytokine levels and cognitive performance in patients with bipolar disorder. Additionally, changes in cytokine levels and cognitive function were correlated only in patients with specific ALDH2 genotypes. |
| Date: | 2018-07 |
| Relation: | Australian and New Zealand Journal of Psychiatry. 2018 Jul;52(7):680-689. |
| Link to: | http://dx.doi.org/10.1177/0004867417720517 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0004-8674&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000438555000009 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85043309550 |
| Appears in Collections: | [其他] 期刊論文
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| PUB28778129.pdf | | 532Kb | Adobe PDF | 346 | View/Open |
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